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Titlebook: DNA Replication - Damage from Environmental Carcinogens; Huidong Zhang Book 2015 The Author(s) 2015 Cell activities.DNA damage.DNA repliso

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发表于 2025-3-21 17:40:09 | 显示全部楼层 |阅读模式
书目名称DNA Replication - Damage from Environmental Carcinogens
编辑Huidong Zhang
视频video
概述Linking three important issues in cell biology - environmental carcinogens, DNA damage and DNA replication.Discussing the fate of DNA replisome upon encountering DNA damage.Illustrating the effects of
丛书名称SpringerBriefs in Biochemistry and Molecular Biology
图书封面Titlebook: DNA Replication - Damage from Environmental Carcinogens; Huidong Zhang Book 2015 The Author(s) 2015 Cell activities.DNA damage.DNA repliso
描述This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.
出版日期Book 2015
关键词Cell activities; DNA damage; DNA replisome; Environmental carcinogens; Experiment protocols
版次1
doihttps://doi.org/10.1007/978-94-017-7212-9
isbn_softcover978-94-017-7211-2
isbn_ebook978-94-017-7212-9Series ISSN 2211-9353 Series E-ISSN 2211-9361
issn_series 2211-9353
copyrightThe Author(s) 2015
The information of publication is updating

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Effect of Environmental Carcinogens on Cellular Physiology,osis through different manners and promote cell proliferation through the inhibition of cell apoptosis. Gene expression is affected by carcinogens mainly through the activation of signaling pathways and interaction with cellular DNA.
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Protocols for Studies of Bypass of DNA Damage by DNA Polymerase,mage. Kinetic analysis contains steady-state kinetic analysis of single dNTP incorporation against DNA damage, full-length extension beyond DNA damage, pre-steady-state kinetic analysis of dNTP incorporation, and kinetic analysis of conformational change. This analysis gave details about how a DNA polymerase bypasses DNA damage.
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https://doi.org/10.1007/978-3-031-22485-0rrect dNTP can be selected and incorporated opposite template base. DNA polymerization consists of several steps. DNA polymerases can be classified into different families, and their functional domains include thumb, palm, figure, and other assistant domains.
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https://doi.org/10.1007/978-3-030-59535-7DNA damage, the replisome will have different fates. Some DNA replisome bypass DNA damage with the aid of protein interactions or other assistant proteins in the replisome. Other replisome will dissociate according to some specific pathways.
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https://doi.org/10.1007/978-3-030-59535-7thology. Carcinogens regulate cell cycle by activation of some cellular signal pathways or formation of DNA damage. Carcinogens also induce cell apoptosis through different manners and promote cell proliferation through the inhibition of cell apoptosis. Gene expression is affected by carcinogens mai
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