Titlebook: DNA Replication; Methods and Protocol Sonya Vengrova,Jacob Z. Dalgaard Book 2009 Humana Press 2009 DNA.DNA replication.Elongation.Microarra

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Analyzing Origin Activation Patterns by Copy Number Change Experiments

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Methods in Molecular Biologyhttp://image.papertrans.cn/d/image/260189.jpg

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DNA Replication978-1-60327-815-7Series ISSN 1064-3745 Series E-ISSN 1940-6029

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Detection of Replication Origins Using Comparative Genomics and Recombinational ARS Assaysequence elements that direct origin activity is however still not straightforward, even in the yeast . which has the best characterised eukaryotic replication origins. The availability of genome sequences for a series of closely related (sensu stricto) budding yeasts has allowed us to take a ‘compa

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Lecture Notes in Computer Sciencedidate replication origin sequences in the . genome, and how large numbers of such candidate sites can simultaneously be assayed for ability to initiate replication. Similar approaches could potentially be used to identify protein-binding sequence elements having other functions, as well as replication origin sites in other species.

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Detection of Replication Origins Using Comparative Genomics and Recombinational ARS Assaydidate replication origin sequences in the . genome, and how large numbers of such candidate sites can simultaneously be assayed for ability to initiate replication. Similar approaches could potentially be used to identify protein-binding sequence elements having other functions, as well as replication origin sites in other species.