Titlebook: DNA Repair; Methods and Protocol Lata Balakrishnan,Jason A. Stewart Book 2019 Springer Science+Business Media, LLC, part of Springer Nature

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书目名称DNA Repair影响因子(影响力)




书目名称DNA Repair影响因子(影响力)学科排名




书目名称DNA Repair网络公开度




书目名称DNA Repair网络公开度学科排名




书目名称DNA Repair被引频次




书目名称DNA Repair被引频次学科排名




书目名称DNA Repair年度引用




书目名称DNA Repair年度引用学科排名




书目名称DNA Repair读者反馈




书目名称DNA Repair读者反馈学科排名

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Resolving Roadblocks to Telomere Replicationon. The terminal position, repetitive sequence, and structural complexities of the telomeric DNA make the telomere an inherently difficult region to replicate within the genome. Thus, despite functioning to protect genome stability mammalian telomeres are also a source of replication stress and have

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Methods to Study Trinucleotide Repeat Instability Induced by DNA Damage and Repaired by DNA replication, repair, recombination, and gene transcription. Somatic TNR instability is involved in the progression of TNR expansion diseases and can be modulated by DNA damage repair and gene transcription. Recent studies from our group and others have shown that DNA base damage and its re

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Extracting and Measuring dNTP Pools in ility. Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in dNTP synthesis and altered regulation of RNR leads to imbalanced dNTP pools. Increased dNTP levels are mutagenic and have the potential to interfere with pathways that are involved in DNA replication, repair and DNA damage con

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Conversion Tract Analysis of Homology-Directed Genome Editing Using Oligonucleotide Donorsnversion tract is defined as the amount of genetic information that is converted from the homology donor to a given strand of the targeted chromosomal locus. Because of this, conversion tract analysis retrospectively not only elucidates the mechanism of homology-directed genome editing but also prov

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Reporter Assays for BER Pathwayamages induced by free radicals and ionizing radiation. Deregulation or deficiencies in BER mechanisms increase the level of mutations leading to carcinogenesis, and single-strand DNA break formation, which may be converted to double-strand breaks and induce apoptosis. BER deficiency is associated w

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Methods for Studying DNA Single-Strand Break Repair and Signaling in , Egg ExtractsUnrepaired SSBs compromise DNA replication and transcription programs, leading to genome instability, and have been implicated in many diseases including cancer. In this chapter, we introduce methods to study the ATR-Chk1 DNA damage response (DDR) pathway and DNA repair pathway in response to a site

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Chromatin Immunoprecipitation (ChIP) of Plasmid-Bound Proteins in , Egg Extractsitation (ChIP) to detect the interaction of proteins with plasmid DNA incubated in extract. The combination of ChIP and . egg extracts provides a highly versatile and tractable approach to analyze dynamic protein–DNA interactions with great spatial and temporal detail.