| 书目名称 | D-type Cyclins and Cancer |
| 编辑 | Philip W. Hinds,Nelson E. Brown |
| 视频video | |
| 概述 | Provides emphasis on functional aspects of D-type cyclins on mammalian tissue.Reviews existing mouse models of cyclin D-deficiency.Discusses potential of D-type cyclins as feasible therapeutic cancer |
| 丛书名称 | Current Cancer Research |
| 图书封面 |  |
| 描述 | .This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devo |
| 出版日期 | Book 2018 |
| 关键词 | D1-S transition; cyclin protein; human tumors; oncogenes; tumorigenesis; Cell Cycle Analysis |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-64451-6 |
| isbn_softcover | 978-3-319-87797-6 |
| isbn_ebook | 978-3-319-64451-6Series ISSN 2199-2584 Series E-ISSN 2199-2592 |
| issn_series | 2199-2584 |
| copyright | Springer International Publishing AG 2018 |
发表于 2025-3-21 18:25:37
