Titlebook: Cytotoxic Drug Resistance Mechanisms; Robert Brown,Uta Böger-Brown Book 1999 Humana Press 1999

卡死偷电

5-Fluorouracil Metabolizing Enzymes,es, and has single-agent activity in colorectal cancer. 5-FU itself is inactive and requires intracellular conversion to form cytotoxic nucleotides (.). Several cellular targets for fluoropyrimidines have been well-characterized, including inhibition of thymidylate synthase (TS) by fluorodeoxyuridin

LUMEN

Offbeat

哀求

Measurement of Drug-Induced DNA Interstrand Crosslinking Using the Single-Cell Gel Electrophoresis aematological malignancies. Many commonly used clinical agents, such as members of the nitrogen mustard, chloroethylnitrosourea, dimethane-sulphonate and platinum classes, are bifunctional. DNA interstrand crosslinks (ISC) formed in cells are clearly critical cytotoxic lesions and the formation of D

同义联想法

PCR Analysis of Microsatellite Instability,phic nature have been widely utilized as genetic markers (.). They consist of a repeating unit of 1–5 base pairs, averaging 25–60 bases in length, and are commonly found in the form d(CA)n:d(GT)n (.). It has been estimated that there are approximately 100,000 CA/GT repeat sequences in the human geno

BUOY

,,-Alkylguanine-DNA Alkyltransferase Assay,diated . alkylation at the ..position of guanine in DNA (.–.). Repair of such adducts can be mediated by ..-alkylguanine-DNA alkyltransferase (ATase) (.,.). Both pro- and eukaryote ATases transfer alkyl groups from the ..-position of guanine in alkylated DNA (or from other low molecular weight subst

助记

AXIOM

GULLY

Redundant