Titlebook: Cytokines in Human Health; Immunotoxicology, Pa Robert V. House,Jacques Descotes Book 2007 Humana Press 2007 Chemokine.Endoplasmatisches Re

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Microbial Exploitation and Subversion of the Human Chemokine Network,ion of the mechanisms underlying these processes should provide opportunities for the generation of novel therapeutics. These may be of use to both thwart the microbial defense strategies and also to treat a variety of inflammatory diseases in which the inappropriate or excessive production of chemokines is pathologically implicated.

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Clinical Adverse Effects of Cytokines on the Immune System,ectly involved in the pathogenesis of immune-mediated inflammatory disorders and autoimmune diseases, it is not surprising that such disorders develop after the administration of pharmacological doses of these cytokines. Another adverse consequence is the development of cytokine-specific antibodies in the sera of treated patients.

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https://doi.org/10.1007/978-3-030-29817-3gained widespread use. Finally, intracellular cytokine staining has provided detailed and invaluable information on the immune responses. This chapter describes the most widespread techniques for measuring cytokines. In addition, it tries to suggest which technique may be the optimal choice for specific purposes.

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John S. Andrews,Roger M. Pinderveral in vitro assays that have been useful for monitoring the immunological effects of cytokine therapy in humans will be discussed in this chapter. Each technique has advantages and limitations and no single assay has been found to reliably predict antitumor efficacy during clinical immunotherapy.

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Cytokine Measurement Tools for Immunotoxicology,gained widespread use. Finally, intracellular cytokine staining has provided detailed and invaluable information on the immune responses. This chapter describes the most widespread techniques for measuring cytokines. In addition, it tries to suggest which technique may be the optimal choice for specific purposes.

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Evaluation of Antibodies in Clinical Trials of Cytokines,lize the biological effect of a cytokine, it is necessary to perform a bioassay. The significance of cytokine immunogenicity can only be understood in the context of antibody testing data coupled with clinical data related to effects on the patient.