Titlebook: Cytokines and Joint Injury; Wim B. Berg,Pierre Miossec Book 2004 Springer Basel AG 2004 Arthritis.bone.cytokine.cytokines.diseases.inflamm

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Cell-cell contact in chronic inflammation: the importance to cytokine regulation in tissue destruct cells, neutrophils and mononuclear phagocytes. This influx of inflammatory cells in the target tissue is associated with the proliferation of invading and resident cells and frequently with destruction and remodeling of the extracellular matrix. In the joint structures, the destruction of the organ

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The role of proteinases in joint tissue destruction,ne can be destroyed. Cartilage contains different types of collagen [.], rod-shaped molecules that aggregate in a staggered array to form cross-linked fibers giving connective tissues strength and rigidity. Trapped between these collagen fibers are the aggrecan molecules [.] that consist of three gl

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Cytokine regulation of bone destruction,s in humans is being remodeled [.]. The growth, development and maintenance of bone is a highly regulated process [.]. Morphogenesis and remodeling of bone involve coordinate regulation of bone-forming cells (osteoblasts) and bone-resorbing cells (osteoclasts) [.,.]. Osteoblasts and osteoclasts aris

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Jochen H. O. Hoffmann,Alexander H. Enk inflammation and autoimmune diseases. The most salient and relevant properties of IL-1 in inflammation are the initiation of cyclooxygenase type 2 (COX-2), type 2 phospholipase A and inducible nitric oxide syntha se (iNOS). This accounts for the large amount of prostaglandin-E. (PGE.), platelet act

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https://doi.org/10.1007/978-3-319-13081-1. Although the precise aetiopathogenesis of these inflammatory arthropathies have not been elucidated, inflammation and damage are common features. Active joint inflammation results in pain, stiffness and dysfunction. Chronic synovitis leads to cartilage and bone damage through mechanisms that have