Titlebook: Cytokines and Autoimmune Diseases; Vijay K. Kuchroo,Nora Sarvetnick,Lindsay B. Nichol Book 2002 Springer Science+Business Media New York 2

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Variant Ligands, Altered T Cell Receptor Signaling, Hierarchical Response Thresholds, and CD4+ Effecire is produced by selection in the thymus of precursor T cells bearing clonally distributed TCR, based on the nature of signals generated by receptor interaction with ligands comprised of self-peptides bount to major histocompatibility complex (MHC) class I or class II molecules (.). In the periphe

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CD1d-Restricted NK T Cells and Autoimmunityc studies demonstrate that a combinatorial admixture of susceptibility and protective genes influences development of disease (.). Longitudinal studies on twins or large cohorts of at-risk individuals indicate that many high-risk subjects do not develop overt disease (., .). In fact, once the nefari

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Role of T Cell Death and Cytokines in Autoimmunity total number of immune cells can increase is often attributalbe to a 1000- to 50,000-fold expansion of the lymphocytes specific for the antigens of the microbe. At the same time, the immune system continuously generates new lymphocytes, each specific for a different antigen, in the hope that one or

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The Role of Cytokines in Induction and Regulation of Autoimmune Uveitised to have an autoimmune or immune-mediated origin. It can affect the front, middle, or back part of the eye, and is then termed anterior, intermediate, and posterior uveitis, respectively. A schematic drawing of a human eye is shown in Fig. 1. The uveitic conditions that affect the back of the eye

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