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Titlebook: Cytokine Storm Syndrome; Randy Q. Cron,Edward M. Behrens Book 20191st edition Springer Nature Switzerland AG 2019 Hemophagocytic lymphohis

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书目名称Cytokine Storm Syndrome
编辑Randy Q. Cron,Edward M. Behrens
视频video
概述Provides the fundamental basic and applied clinical science at the cutting edge of CSS treatment.First textbook devoted to Cytokine Storm Syndromes, covering all aspects of the disorder (clinical, gen
图书封面Titlebook: Cytokine Storm Syndrome;  Randy Q. Cron,Edward M. Behrens Book 20191st edition Springer Nature Switzerland AG 2019 Hemophagocytic lymphohis
描述.Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals...A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research,to clinical presentations, risk factors, and treatment..
出版日期Book 20191st edition
关键词Hemophagocytic lymphohistiocytosis; Macrophage activation syndrome; Perforin; Cytolysis; Genetics; Cytoki
版次1
doihttps://doi.org/10.1007/978-3-030-22094-5
isbn_softcover978-3-030-22096-9
isbn_ebook978-3-030-22094-5
copyrightSpringer Nature Switzerland AG 2019
The information of publication is updating

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Clinical Features of Cytokine Storm Syndrome coagulopathy, cytopenia, skin rash, and variable neurologic symptoms. The clinical presentations of CSS can be similar. The clinical features of CSS may be difficult to distinguish from those of the underlying diseases. Awareness of the disease and highly suspecting CSS in patients with some of the
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Laboratory Features and Pathology of the Cytokine Storm Syndromese), the laboratory findings associated with these diseases, and the currently recommended diagnostic strategies. The pathogenesis of primary forms of hemophagocytic lymphohistiocytosis (HLH) is based on an impaired function of cytotoxic T-lymphocytes and NK cells, which then leads to an inability of
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Genetics of Primary Hemophagocytic Lymphohistiocytosis that are associated with each syndrome. Additionally, we place primary hemophagocytic lymphohistiocytosis into four distinct categories, depending on the presence or absence of hypopigmentation and susceptibility to Epstein–Barr virus-induced lymphoproliferative disease.
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Genetics of Acquired Cytokine Storm Syndromesers leading to strong immunological activation, without any known genetic predilection. However, recent studies have suggested that existing underlying genetic factors may synergize with particular diseases and/or environmental triggers (including infection, autoimmune/autoinflammatory disorder, or
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CD8+ T Cell Biology in Cytokine Storm Syndromesed for release of perforin-containing cytotoxic granule constituent. Perforin is expressed by subsets of CD8. T cells and NK cells, representing lymphocytes that share mechanism of target cell killing yet display distinct modes of target cell recognition. Here, we highlight recent findings concernin
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Immunology of Cytokine Storm Syndromes: Natural Killer Cellsrticular interest in primary hemophagocytic lymphohistiocytosis (pHLH) since all of the genetic defects associated with this disorder cause diminished cytotoxic capacity of NK cells and T lymphocytes, and assays of NK cell killing are used clinically for the diagnosis of HLH. Herein, we review human
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