| 书目名称 | Cystic Fibrosis | | 副标题 | Infection, Immunopat | | 编辑 | Richard B. Moss | | 视频video | | | 丛书名称 | Allergy and Immunology | | 图书封面 |  | | 描述 | This work is concerned with Cystic Fibrosis (CF), the most common fatal genetic disease in the Caucasian population. The decade of the 1980s was one of spectacular progress in understanding the genetic and molecu lar basis of CF. The research breakthroughs of the decade began with the first fundamental insights, published in 1981-1983, into the basic cellular pathophysiology of CF with demonstrations of altered ion transport in spe cialized exocrine epithelial tissues (1-3). Research progress shifted into a triumph of "reverse genetics," using restriction-fragment-Iength polymor phism DNA technology (4), with the localization of the CF gene to a region of chromosome 7 (5-7). Understanding, accelerated by an explOSion of in vitro methodologies for epithelial cell culture and transformation, allowed and physiological studies (8-11); these focused, controlled biochemical with increasing precision, on the molecular pathology of distal steps in the regulatory pathways for epithelial ion transport (12-19). Finally, the "end of the beginning" occurred in late 1989 with one of the great achievements of molecular genetics, the isolation and cloning of the CF gene (20). As a result, we no | | 出版日期 | Book 1990 | | 关键词 | allergy; bacteria; cell biology; infection; infections; infectious disease; inflammation; pathology; pseudom | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4612-0475-6 | | isbn_softcover | 978-1-4612-6778-2 | | isbn_ebook | 978-1-4612-0475-6 | | copyright | Springer Science+Business Media New York 1990 |
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发表于 2025-3-21 17:51:45
