Titlebook: Cyclosporin; Mode of Action and C Angus W. Thomson (Reader in Immunology) Book 1989 Kluwer Academic Publishers 1989 T cell.bone marrow.cell

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978-94-010-6874-1Kluwer Academic Publishers 1989

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Heart – Coronary Vessels and CardiomyocytesSince the effect of Sandimmun. (cyclosporin A) was established in organ transplantation some years ago, increasing interest has been shown in studying its potential in autoimmune diseases. As of June 1988, about 5000 patients suffering from many different clinical syndromes have been treated in more than 100 clinical studies.

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,Cyclosporin A (Sandimmun®) in autoimmune disorders,Since the effect of Sandimmun. (cyclosporin A) was established in organ transplantation some years ago, increasing interest has been shown in studying its potential in autoimmune diseases. As of June 1988, about 5000 patients suffering from many different clinical syndromes have been treated in more than 100 clinical studies.

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Cyclosporin A in insulin-dependent diabetes,ts have shown a favourable effect but problems persist which still preclude large-scale use of this new clinical application of CsA. In this article we shall review the main features of the use of CsA in experimental and clinical diabetes mellitus.

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Dagmara Mohuczy,M. Ian Phillipsfungi . and . that showed strong . immunosuppressive activity in micer but was otherwise well tolerated. Their influential publication on the properties of CsA in 1976. led to successful clinical trials, and the drug is now in routine use in organ transplantation. It also shows promise in the preven

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Immunohistochemistry of Angiotensins group in 1976., CsA has proved an effective and valuable agent for suppression of allograft rejection in animals and has found widespread clinical acceptance.. CsA is highly specific for lymphocytes and this property suggested that these cells possess some unique features of growth control which m