| 书目名称 | Cyclooxygenases | | 副标题 | Methods and Protocol | | 编辑 | Samir S. Ayoub,Roderick J. Flower,Michael P. Seed | | 视频video | | | 概述 | Serves as a detailed step-by-step laboratory manual covering the most up-to-date, widely used protocols to study the biology of the cyclooxygenase enzymes.Includes chapters written by some of the pion | | 丛书名称 | Methods in Molecular Biology | | 图书封面 |  | | 描述 | .Since the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflammatory drugs (NSAIDs), much research has gone into the development of methods to study the biological functions of COX-1 and COX-2. In .Cyclooxygenases: Methods and Protocols., experts and pioneers in the field present the most up-to-date in vitro and in vivo techniques routinely used in COX research. The volume delves into essential topics such as the purification, cloning, and expression of COX enzymes as well as in vitro assays aimed at determining the inhibitory potency of drugs on COX-1 and COX-2 activities, with chapters describing protocols used for the extraction and measurement of the prostanoids. This volume also describes in vivo disease models used to study the roles of COX-1 and COX-2 in gastrointestinal injury, inflammation, and pain. As a book in the highly successful .Methods in Molecular Biology™. series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and | | 出版日期 | Book 2010 | | 关键词 | COX-1 and COX-2; Cyclooxygenase enzymes; Disease processes; Expression; In vivo models; Inhibition patter | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59745-364-6 | | isbn_softcover | 978-1-4939-5638-8 | | isbn_ebook | 978-1-59745-364-6Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2010 |
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发表于 2025-3-21 19:29:58
