Titlebook: Chemistry and Biology of O-GlcNAcylation; Wen Yi Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spr

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粘土

lethargy

O-GlcNAcylation and Cell Metabolism,l activities of organism. O-GlcNAcylation is derived from the hexosamine biosynthetic pathway, which integrates the metabolism from glucose, glutamine, acetyl-CoA, and nucleotides. O-GlcNAcylation levels fluctuate with the concentration of these metabolites and thus are considered as the “metabolic

萤火虫

O-GlcNAcylation in Transcriptional Regulation and Epigenetics, we will focus on its role on transcription. We will first review new methodologies to study chromatin-bound .-GlcNAcylated proteins. Then we will venture into different organisms, including flies, humans, and plants, and summarize the role of OGT in transcription. In flies, we will emphasize the ro

令人悲伤

OASIS

O-GlcNAcylation and Stem Cells,l and pluripotency. These two properties are intricately regulated through complex mechanisms during early embryogenesis and development. Recent evidence has shown that O-GlcNAcylation plays a pivotal role in regulating stem cell identity and cell fate decision. Here, we summarize key developments i

OASIS

-GlcNAcylation and Immune Regulation,ce, phosphorylation, .-GlcNAcylation is a reversible covalent modification that regulates the stability, activity, and localization of target proteins. As such, .-GlcNAcylation regulates the development of the immune system and many phases of the immune response, including its initiation, propagatio

馆长

上腭

健谈

Profiling O-GlcNAcylation with Mass Spectrometry,itivity and throughput properties has become widely used for comprehensive characterization of O-GlcNAcylation, enabling in-depth understanding of their biological roles these years. Herein, the chapter would provide a comprehensive update of MS-based methodologies for quali-quantitative characterization of O-GlcNAcylated proteins.