Titlebook: Cyclin Dependent Kinase 5 (Cdk5); Li-Huei Tsai,Nancy Y. Ip Book 2008 Springer-Verlag US 2008 Alzheimer.Cdk5.Neuron.genes.migration.neurode

Calculus

CDK5 and Mitochondrial Cell Death Pathways,multicellular organisms during development. The same apoptotic machinery can be reactivated in the adult organism under disease conditions. Mitochondria play a central role in many apoptotic cascades, both as a storage place for pro-apoptotic molecules and for the production of ATP that is required

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Regulation and Function of Cdk5 in the Nucleus,rocesses. This seems to distinct Cdk5 from other more traditional Cdks. However, recent discoveries have now extended the role of Cdk5 to the nucleus. This chapter summarizes these novel findings. These include the detection of Cdk5 and its regulators in the nucleus, identification of nuclear target

DOSE

Cdk5 May Be an Atypical Kinase, but Not in the Way You Think, but genetically distinct. Analysis of the Cdk5 knockout (or the double p35/p39 knockout) has led to the view that the primary function of Cdk5 is in the migration and maturation of embryonic post-mitotic neurons. The literature has no reference to a role of Cdk5 in normal cell cycle regulation. Rec

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羊齿

,Protein–Protein Interactions Involving the N-Terminus of p35,rminus to form the protein p25. Although p25 is equally potent in activating Cdk5 as p35, it displays a number of differences from the latter, indicating an indispensable role of the N-terminal region for carrying out many of the Cdk5-p35 activities. A number of proteins have been identified that in

果核

The Kinase Activity of Cdk5 and Its Regulation,In this chapter we describe the enzymatic properties and the regulation mechanisms of Cdk5 activity in post-mitotic neurons in comparison to cell cycle Cdks. The regulation mechanisms are synthesis and degradation of p35, the interaction with p35- or Cdk5-binding proteins, phosphorylation of Cdk5 or

效果

The Structural Bases of CDK5 Activity,f protein kinases are usually structurally alike, a requirement imposed by the necessity to maintain the basic geometry of a highly conserved machinery required for good catalytic output. Conversely, the structures of the inactive states of kinase-family members can vary widely from each other, a pr

馆长

Cdk5, a Journey from Brain to Pain: Lessons from Gene Targeting,ires binding with its activator p35 and/or p39 to execute its kinase activity. Cdk5 was initially identified by purification from bovine brain extract and termed “Cdk5” because of its nucleotide sequence homology with human CDC2. Since the discovery of this kinase in 1992, it has been extensively st

Fibrin

Involvement of Cdk5 in Synaptic Plasticity, and Learning and Memory,dk5 in synaptic plasticity, and learning and memory. In this chapter, we summarize the data that reveal the involvement of Cdk5 in mnemonic processes on molecular as well as cellular levels and relate these findings to its emerging function in learning and memory. From amongst the impressive range o