| 书目名称 | Current Topics in Microbiology and Immunology | | 副标题 | Volume 102 | | 编辑 | M. Cooper,P. H. Hofschneider,R. Zinkernagel | | 视频video | http://file.papertrans.cn/242/241382/241382.mp4 | | 丛书名称 | Current Topics in Microbiology and Immunology | | 图书封面 |  | | 描述 | Binding of various ligands (hormones, neurotransmitters, immunological stimuli) to membrane receptors induces the following changes: 1. Receptor redistribution (clustering, "capping") 2. Conformational changes that can be detected by fluorescent probes 3. Alteration in membrane fluidity (spin label and fluorescence polarization probes) 4. Changes in fluxes of ions and metabolites 5. Increased phospholipid turnover (especially of phosphatidyl inositol) 6. Activation of membrane-bound enzymes (adenyl cyclase, ATPase, transmethylases). Some of the early changes resulting from or associated with the binding (adsorption) of virions to the host cell membrane are of the same type. Adsorption of animal viruses to cells is the ftrst step in a chain of events resulting in the production of progeny virus on the one hand and in damage to cells and tissues on the other. In the classical studies of viral infection, cells are adsorbed with virus, usually for 60 min, and the changes induced by the virus in the host cell are recorded thereafter. In the past decade, more and more studies have been aimed at the events occurring in these ftrst 60 min of the so-called adsorption period. These studies d | | 出版日期 | Book 1983 | | 关键词 | ATPase; cell; immunology; infection; microbiology; protein; proteins; virus | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-68906-2 | | isbn_softcover | 978-3-642-68908-6 | | isbn_ebook | 978-3-642-68906-2Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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