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Titlebook: Current Topics in Microbiology and Immunology; W. Henle,P. H. Hofschneider,P. K. Vogt Book 1981 The Editor(s) (if applicable) and The Auth

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The Transforming Protein of Avian Sarcoma Viruses and Its Homologue in Normal Cells,n. They produce fibrosarcomas upon injection into a variety of avian and mammalian species and rapidly transform avian fibroblasts in culture. Investigation with these viruses is aided greatly by the fact that the transforming agent is nondefective (nd) replicating without a helper virus, and this f
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Gene-Specific Probes for Avian Retroviruses,t provide clues in our studies of cancer etiology or developmental biology. One of the most notable was the discovery of reverse transcriptase. This marked a momentous occasion in the history of molecular biology. Not only did it provide insight into the mechanism of persistence of retroviruses but
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The Obese Strain (OS) of Chickens With Spontaneous Autoimmune Thyroiditis: Review of Recent Data,hat the clinical symptoms are attributable to a spontaneously arising thyroiditis which is autoimmune in nature was first recognized 5 years later [3]. In subsequent years this avian model was established as the closest counterpart to human Hashimoto’s disease [4]; the data accumulated by 1974 have
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Reducibility Among Combinatorial Problemsells in tissue culture and cause neoplastic disease in animals. Studies of these viruses have led to the identification of more than ten distinct transforming genes and proteins, and have provided important insights into possible mechanisms of oncogenesis.
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Book 1981d thus provided us with the frrst means of isolating gene-spe­ cific probes. Finally, the laboratories which have mapped the genome have provided us with the framework in which to ask very specific questions with our gene-specific probes. Recently, numerous excellent reviews concerning various aspec
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