Titlebook: Current Topics in Innate Immunity II; John D. Lambris,George Hajishengallis Book 2012 The Editor(s) (if applicable) and The Author(s), und

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candle

Granzyme B: A New Crossroad of Complement and Apoptosis,sis cascade. Although possible crossroads between both systems have been proposed, little is known about the underlying molecular interactions. In this study a new interaction interface is presented for C3a and C5a generation by the pro-apoptotic factor granzyme B. In vitro incubation of the central

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Platelets, Complement, and Contact Activation: Partners in Inflammation and Thrombosis, Here we review the interactions between activated platelets and the complement and contact activation systems in clotting blood. Chondroitin sulfateA (CS-A), released from alpha granules during platelet activation, is a potent mediator of crosstalk between platelets and the complement system. CS-A

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,Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection, critical role in the development of an anti-inflammatory T cell subset called regulatory T (Treg) cells. Two NF-κB proteins, c-Rel and p65, drive the development of Treg cells by promoting the formation of a .-specific enhanceosome. Consequently, c-Rel-deficient mice have marked reductions in Treg

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glomeruli

Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseaseeen adopted into varied fields including immunology. After fertilization, larvae survive with only the innate immune responses because adaptive immune system is morphologically and functionally mature only after 4–6 weeks postfertilization. This temporal separation provides a suitable system to stud

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Monocyte-derived Inflammatory Dendritic Cells in the Granuloma During Mycobacterial Infection, the complex, changing role of this subset during mycobacterial infection. Studies demonstrate that in addition to sustaining a systemic anti-mycobacterial response, the inflammatory dendritic cell subset present in .-induced granulomas also influences local immune regulation within the granuloma ov