书目名称 | Current Directions in Radiopharmaceutical Research and Development |
编辑 | Stephen J. Mather |
视频video | http://file.papertrans.cn/242/241183/241183.mp4 |
丛书名称 | Developments in Nuclear Medicine |
图书封面 |  |
描述 | Radiophannaceutical research has recently undergone a major change in direction. In past years it has been concerned mainly with the development of perfusion tracers, the biodistribution of which reflect the regional blood flow to areas of major organs such as the heart and brain. However, a major new direction of interest now lies in the development of receptor-binding radio-tracers which can be used to perform in-vivo characterisation of diseased tissues and it is likely that much of the future research in this field will follow this direction. The difficulties in developing such tracers are considerable. The researcher must first identify a promising target for radiopharmaceutical development. High specific activity radioactive molecules must be designed and synthesised which will both bind to the target receptor with high affinity, and also have the physicochemical characteristics which will allow them to reach the target site in sufficient quantity while at the same time showing minimal uptake in non-target tissues. Thus the knowledge base required for radiophannaceutical development has now expanded beyond the limits of radiopharmaceutical chemistry to include aspects of bioc |
出版日期 | Book 1996 |
关键词 | CNS; cell; chemistry; computer; diagnostic imaging; hormones; imaging; positron emission tomography (PET); r |
版次 | 1 |
doi | https://doi.org/10.1007/978-94-009-1768-2 |
isbn_softcover | 978-94-010-7289-2 |
isbn_ebook | 978-94-009-1768-2 |
copyright | Kluwer Academic Publishers 1996 |