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Titlebook: Current Directions in Radiopharmaceutical Research and Development; Stephen J. Mather Book 1996 Kluwer Academic Publishers 1996 CNS.cell.c

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书目名称Current Directions in Radiopharmaceutical Research and Development
编辑Stephen J. Mather
视频videohttp://file.papertrans.cn/242/241183/241183.mp4
丛书名称Developments in Nuclear Medicine
图书封面Titlebook: Current Directions in Radiopharmaceutical Research and Development;  Stephen J. Mather Book 1996 Kluwer Academic Publishers 1996 CNS.cell.c
描述Radiophannaceutical research has recently undergone a major change in direction. In past years it has been concerned mainly with the development of perfusion tracers, the biodistribution of which reflect the regional blood flow to areas of major organs such as the heart and brain. However, a major new direction of interest now lies in the development of receptor-binding radio-tracers which can be used to perform in-vivo characterisation of diseased tissues and it is likely that much of the future research in this field will follow this direction. The difficulties in developing such tracers are considerable. The researcher must first identify a promising target for radiopharmaceutical development. High specific activity radioactive molecules must be designed and synthesised which will both bind to the target receptor with high affinity, and also have the physicochemical characteristics which will allow them to reach the target site in sufficient quantity while at the same time showing minimal uptake in non-target tissues. Thus the knowledge base required for radiophannaceutical development has now expanded beyond the limits of radiopharmaceutical chemistry to include aspects of bioc
出版日期Book 1996
关键词CNS; cell; chemistry; computer; diagnostic imaging; hormones; imaging; positron emission tomography (PET); r
版次1
doihttps://doi.org/10.1007/978-94-009-1768-2
isbn_softcover978-94-010-7289-2
isbn_ebook978-94-009-1768-2
copyrightKluwer Academic Publishers 1996
The information of publication is updating

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The Development of Radiopharmaceuticals for Imaging CNS Receptors,ciation constant; or K., inhibition constant). When a ligand is bound to a receptor (R) located in the cell membrane, the ligand-receptor complex triggers responses of secondary messengers (i.e., induce protein kinase activity). There is a large number of CNS receptors responsible for different types of neuronal function.
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Computer Modelling of Metal-Based Radiopharmaceuticals,raphics. Most of these packages also make possible wave-mechanical calculations, which are useful in predicting properties such as electronic spectra, and magnetic properties. A selection of computer molecular modelling packages is listed below:
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Maria Lodovica Gullino,Laura Vivanimed by the “zippering” of two complementary single-stranded oligonucleotides by Watson-Crick base pairing can be termed hybridization [1]. It is this property of hybridization, unique to RNA and DNA (if artificial oligomers are excluded), which is likely to render in the near future radiolabeled oligonucleotides useful as radiopharmaceuticals.
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Bifunctional Chelators for Technetium-99m,ociated with technetium is the fact that it cannot simply replace a hydrogen atom as it is the case with halogens like .I and .F, nor can be a substitute for one of the other common atoms in biologically interesting compounds, i.e. carbon, nitrogen or oxygen.
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Therapeutic Radionuclides: Making the Right Choice,chniques that have recently emerged, (e.g., tumor therapy with radiolabeled monoclonal antibodies, treatment of metastatic bone pain, etc.) appear to have provided a substantial impetus to research on production of new therapeutic radionuclides (4–7).
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Labelling Oligonucleotides with Imagable Radionuclides,med by the “zippering” of two complementary single-stranded oligonucleotides by Watson-Crick base pairing can be termed hybridization [1]. It is this property of hybridization, unique to RNA and DNA (if artificial oligomers are excluded), which is likely to render in the near future radiolabeled oligonucleotides useful as radiopharmaceuticals.
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