Titlebook: Current Advances in Osteosarcoma; Eugenie S. Kleinerman, M.D. Book 20141st edition Springer Nature Switzerland AG 2014 bone cancer.cancer.

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https://doi.org/10.1007/978-3-319-04843-7bone cancer; cancer; metastasis; osteosarcoma; pediatric cancer

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Understanding the Role of Notch in Osteosarcomath in malignant cells and nonmalignant components of tumors, make it more difficult to define Notch as simply an oncogene or a tumor suppressor. The cell-autonomous behaviors caused by Notch pathway manipulation may vary between cell lines but can include changes in proliferation, migration, invasiv

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Developmental Pathways Hijacked by Osteosarcomathe normal counterpart’s development can aid in understanding the malignant state. This is certainly true for osteosarcoma and the normal developmental pathways that guide osteoblast development that are changed in the genesis of osteogenic sarcoma. A carefully regulated crescendo–decrescendo expres

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