Titlebook: Current Advances in Osteosarcoma; Eugenie S. Kleinerman, M.D. Book 20141st edition Springer Nature Switzerland AG 2014 bone cancer.cancer.

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Oncolytic Viruses for Potential Osteosarcoma Therapy specific and replication competent viruses. Osteosarcoma is a challenging malignancy to identify novel targets for therapy due to its complex genetic make-up. Oncolytic virotherapy may be a promising approach as a novel therapeutic, not dependent on consistent expression of a single target. In this

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Worship Spaces: 1001–2000 Seatse then validated using independent validation experiments. From these results, we identified four RTKs (Axl, EphB2, FGFR2, and Ret) that have not been previously studied in osteosarcoma and provide targets for the development of novel therapeutics.

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https://doi.org/10.1007/978-1-4939-3097-5ls and pericytes, are the major source of Notch activation in osteosarcoma tumors in vivo and in patients. As a result, Notch pathway expression is not expected to be uniform across a tumor but likely to be highest in those areas immediately adjacent to blood vessels. Therapeutic targeting of the No

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Jarno Drost,Benedetta Artegiani,Hans Clevers sensitivity to GCB in LM7 cells. By contrast, inhibiting autophagy in K7M3 cells decreased GCB sensitivity. Defining the role autophagy plays in chemotherapy response in different tumor types has become of greater importance in order to identify the best suitable therapeutic approach. In this chapt

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