Titlebook: Crystallographic Methods and Protocols; Christopher Jones,Barbara Mulloy,Mark R. Sanderson Book 1996 Humana Press 1996

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ction intensities and those calculated improves. This improved agreement between observed and calculated structure factors leads to better phases and, concomitantly, to improved electron density maps. The refinement process is monitored by the conventional crystallographic R factor, defined by the equation:

Mendacious

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Structure Determination Using Isomorphous Replacement,sful application to large biological molecules was undertaken in 1954 by Perutz and coworkers (.) while studying hemoglobin. Since then, this method has played a central role in the determination of almost all unique protein and nucleic acid structures, and it is likely to retain such a role in the foreseeable future.

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defibrillator

Refinement of Protein and Nucleic Acid Structures,ction intensities and those calculated improves. This improved agreement between observed and calculated structure factors leads to better phases and, concomitantly, to improved electron density maps. The refinement process is monitored by the conventional crystallographic R factor, defined by the equation:

orthodox

The Crystallization and Structure Analysis of Oligonucleotide Sequences, relatively sparse para-crystalline diffraction data from ordered fibers. It is a tribute to the sophistication of these analyses, in spite of the inherent limitations of fiber data, that the refined “canonical” A- and B-DNA double helices are still major reference pomts for many studies (.).

PRO

Anterior

1064-3745 , Crystallographic Methods andProtocols, concentrates on the use of X-ray crystallography to solve the detailed three­ dimensional structuresofproteins, nucleic acids, andtheir complexes. Such a structure determination is a major undertaking, demands expertise in a range of skills, and requires cons

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The Foreign Policy Election That Wasn’tated the formulation of a common protein-DNA recognition code, which although suggested earlier (.), now appears to be too simplistic (.). However, some general observations have emerged from these recent protein-DNA crystal structures, some of which are discussed below.

有恶臭

Book 1996ographic Methods andProtocols, concentrates on the use of X-ray crystallography to solve the detailed three­ dimensional structuresofproteins, nucleic acids, andtheir complexes. Such a structure determination is a major undertaking, demands expertise in a range of skills, and requires considerable r