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Titlebook: Continuous Pharmaceutical Processing; Zoltan K Nagy,Arwa El Hagrasy,Jim Litster Book 2020 American Association of Pharmaceutical Scientist

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发表于 2025-3-21 19:14:42 | 显示全部楼层 |阅读模式
书目名称Continuous Pharmaceutical Processing
编辑Zoltan K Nagy,Arwa El Hagrasy,Jim Litster
视频video
概述Broadens your understanding of different continuous unit operations involved in drug substance and product manufacturing.Equips readers with the most up-to-date advances in modeling, experimental inve
丛书名称AAPS Advances in the Pharmaceutical Sciences Series
图书封面Titlebook: Continuous Pharmaceutical Processing;  Zoltan K Nagy,Arwa El Hagrasy,Jim Litster Book 2020 American Association of Pharmaceutical Scientist
描述.Continuous pharmaceutical manufacturing is currently receiving much interest from industry and regulatory authorities, with the joint aim of allowing rapid access of novel therapeutics and existing medications to the public, without compromising high quality. Research groups from different academic institutions have significantly contributed to this field with an immense amount of published research addressing a variety of topics related to continuous processing. The book is structured to have individual chapters on the different continuous unit operations involved in drug substance and drug product manufacturing. A wide spectrum of topics are covered, including basic principles of continuous manufacturing, applications of continuous flow chemistry in drug synthesis, continuous crystallization, continuous drying, feeders and blenders, roll compaction and continuous wet granulation.The underlying theme for each of these chapters is to present to the reader the recent advances in modeling, experimental investigations and equipment design as they pertain to each individual unit operation. The book also includes chapters on quality by design (QbD) and process analytical technology (PA
出版日期Book 2020
关键词Continuous Manufacturing; Pharmaceutical Manufacturing; Continuous Pharmaceutical Processing; Drug Subs
版次1
doihttps://doi.org/10.1007/978-3-030-41524-2
isbn_softcover978-3-030-41526-6
isbn_ebook978-3-030-41524-2Series ISSN 2210-7371 Series E-ISSN 2210-738X
issn_series 2210-7371
copyrightAmerican Association of Pharmaceutical Scientists 2020
The information of publication is updating

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发表于 2025-3-21 23:44:37 | 显示全部楼层
Book 2020nderlying theme for each of these chapters is to present to the reader the recent advances in modeling, experimental investigations and equipment design as they pertain to each individual unit operation. The book also includes chapters on quality by design (QbD) and process analytical technology (PA
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https://doi.org/10.1007/978-3-322-86398-0e been run at manufacturing scale in PFRs. Mean residence time ranges from 0.7 to 24 h in the 11 examples; therefore, it is not necessary for a reaction to be extremely fast in order to be a viable candidate for flow chemistry. This chapter gives many general guidelines on how to design and operate
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Vom Nationalismus zum Umweltschutzng theory. With regard to the formulation development aspects of the process, common pharmaceutical excipients and their impact on the resulting ribbon and granule qualities are discussed. Lastly, we present the current state of the art in equipment design and process control that enable the process
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https://doi.org/10.1007/978-3-322-86401-7 model for continuous fluidized bed drying has been developed and implemented as a module within the framework of the stationary flowsheet simulation program ., which allows the simulation of the drying process for many different solids, liquids, and gases..In addition to the residence time distribu
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https://doi.org/10.1007/978-3-322-86403-1strategically placed valves and tees. Inerting is a primary line of defense against fire. Grounding and bonding is used when flowing from one vessel to another to prevent static charge buildup and sparking. Nonconductive liquid flowing through nonconductive tubing at high velocities should be avoide
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https://doi.org/10.1007/978-3-322-86403-1ng continuous production process technologies, where production facility replication through digital twins is becoming a key enabler, the chapter sets out a supply network design and analysis approach that evaluates the commercial and operational viability of alternative manufacturing supply network
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Understanding Residence Time, Residence Time Distribution, and Impact of Surge Vessels,or (CSTR) followed by PFRs in series. For reactor design, RTD for actual product and reagents can be much different than RTD for bulk solvent flow, and therefore it must be measured experimentally for the actual substrate to quantify it precisely. Numerical predictions of RTD based on Peclet number
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