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Titlebook: Continuous Dopaminergic Stimulation in Parkinson’s Disease; Proceedings of the W J. A. Obeso,R. Horowski,C. D. Marsden Conference proceedin

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The case for and concerns about continuous dopamine stimulation in Parkinson’s diseaseluctations in response (“on-off”). This should be manageable with innovative delivery systems for the drugs. However further studies are required to determine if continuous dopaminergic stimulation will be complicated by increased levels of drug metabolites or down regulation of dopaminergic neurotransmission.
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Psychiatric side effects during the treatment of Parkinson’s diseaseicant. When this occurs early in the course of treatment, there is usually a history of prior psychotic illness. Chronic treatment can, however, elicit psychosis in individuals without such a history. The possible pathogenesis of this is reviewed.
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Applications of new drug delivery technologies to Parkinson’s disease and dopaminergic agentsdictable swings in therapeutic efficacy in Parkinson patients with the “on/off” effect, but may even have a role in the future in preventing such fluctuations from developing in patients chronically treated with dopaminergic therapies.
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Conference proceedings 1988ontinuous s.c. infusion of lisuride, a watersoluble dopaminergic 8- -aminoergoline with dopaminergic properties which can be injected or infused, can improve - sometimes quite considerably - motor function in severely disabled fluctuating Parkinsonian patients. The concurrent use of the peripheral d
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