Titlebook: Contemporary Topics in Molecular Immunology; F. P. Inman,W. J. Mandy Book 1981 Plenum Press, New York 1981 Allergie.Antigen.autoimmune dis

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Book 1981nient and necessary to integrate information from several of them. We try to focus on the molecular aspects of immunology as much as is reasonable, but some con­ tributions consist of ablend of molecular and cellular immunology and even immunopathology. This is as it should be, since information at

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Marc Valls,Ildefonso Cases,Víctor de Lorenzophocytes express a cell surface molecule which bears antigenic determinants encoded for by genes in the . region (David .., 1973; Gotze .., 1973; Haupfeld .., 1973; Sachs and Cone, l973;Hämmerling .., 1974), and these molecules have now been termed .-region-associated, or Ia, antigens.

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The Chemistry of Ia Antigens,phocytes express a cell surface molecule which bears antigenic determinants encoded for by genes in the . region (David .., 1973; Gotze .., 1973; Haupfeld .., 1973; Sachs and Cone, l973;Hämmerling .., 1974), and these molecules have now been termed .-region-associated, or Ia, antigens.

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dithiolethione

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The Phenotypic Expression of Rabbit Immunoglobulins: A Model of Complex Regulated Gene Expression aation about the immunoglobulins of the rabbit has accumulated [see, for example, reviews by Mage .., 1973; Kindt, 1975; and .., No. 2, a special issue entitled “Jacques Oudin et les Concepts d’Allotypie des Immunoglobulines et d’Idiotypie des Anticorps,” 1979].

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Idiotypic Regulation in Immune Networks,ts. The clonal selection theory has a great appeal to logic and the elegance of simplicity, and it is in fact able to account for a vast body of data. The central idea of clonal selection is that the immune system is a library of precommitted clones, able to manufacture a pair of V-region polypeptid

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The Chemistry of Ia Antigens,lly to an antigenic challenge (McDevitt and Benacerraf, 1969; Benacerraf and Mc Devitt, 1972). Owing to the potential significance of the genetic control of the immune response by these . genes, an intensive effort has been made to identify the gene products encoded for by the . region and to charac