Titlebook: Contact Dermatitis; Jeanne Duus Johansen,Peter J. Frosch,Jean-Pierre L Book 20115th edition Springer-Verlag Berlin Heidelberg 2011 allery.

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Genetics and Individual Predispositions in Contact Dermatitisous stimulus develop contact dermatitis, allergic or irritant. In addition, several cofactors are involved. Hence, the notion of a complex disease, with probably many genes and many environmental factors contributing to the observed phenotypes. There has been a lack of conclusive results in the stud

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Molecular Aspects in Allergic and Irritant Contact Dermatitisreactions, subsequent to chemical exposure, derive from very different biological mechanisms. For a chemical to be a sensitizer, it must have the ability to bind to protein so that a nonself antigen can be produced. The evidence indicates that normally this binding occurs by covalent bond formation.

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Role of the Permeability Barrier in Contact Dermatitisontact dermatitis, the first step in pathology is the disruption of the skin barrier. The skin barrier often gets disrupted by chronic exposure to water plus detergents or solvents. Thereafter, irritants may penetrate into the skin and induce injury to the keratinocyte cell membrane in the living ep

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