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Titlebook: Contact Dermatitis; Jeanne Duus Johansen,Vera Mahler,Peter J. Frosch Living reference work 20200th edition cutaneous toxicology.exposure

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Historical Aspects of Contact Dermatitis,n 1895. At the same period (1897), the pioneering work of Fabre in the field of contact urticaria is emphasized. Later on, the prominent work by Bruno Bloch in Zurich has led to the universality of the patch testing methodology. In more recent years, a major breakthrough was fulfilled by the foundin
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Genetics and Individual Predispositions in Contact Dermatitis,ous stimulus develop contact dermatitis, allergic or irritant. In addition, several cofactors are involved. Hence, the notion of a complex disease, with probably many genes and many environmental factors contributing to the observed phenotypes. There has been a lack of conclusive results in the stud
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Identification of Allergens in Complex Mixtures and Products,he case of components of complex mixtures such as natural extracts and essential oils. Today, non-animal alternative methods validated to assess the sensitizing potential of chemicals are, overall, unable to completely predict the skin sensitization potential of these complex mixtures of chemicals.
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Histopathological and Immunohistopathological Features of Irritant and Allergic Contact Dermatitis,iagnosis. In contrast, biopsies of patch tests are not recommended, except for scientific purposes. Histopathological features of positive allergic patch test reactions are typical of a spongiotic dermatitis, whereas those of positive irritant patch test reactions are varied (mainly epidermal necros
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