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Titlebook: Connective Tissue; Macromolecular Struc Martin B. Mathews Book 1975 Springer-Verlag Berlin Heidelberg 1975 Bindegewebe.Molekularbiologie.bi

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Collagen,ble working definition can be given, based upon certain common molecular characteristics of this class of protein. Details may be found in reviews by GROSS (1963), RAMACHANDRAN (1967), BAILEY (1968), TRAUB and PIEZ (1971), GALLOP et al. (1972), and E.J. MILLER (1973).
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Structural Glycoproteins,valently bound carbohydrate residues (SPIRO, 1970). However, only a small number of such proteins are known to be present in significant amounts in the extracellular phases of tissues that have structural functions. These proteins fall into three large groups with unique characteristics that require
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Polyanionic Glycans of Cartilage, Bone, and Notochord, of the taxonomic distribution of cartilage. The earlier arguments in favor of the presence of “true” cartilage in invertebrates were summarized by NOWIKOFF (1912). Opinions, still widely prevalent, that cartilage is confined to vertebrates have been expressed by SCHAFFER (1930), LUBOSCH (1938), HYM
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Polyanionic Glycans in Development and Aging of Vertebrate Cartilage,evelopmental sequences tend to be conservative (SMITH, 1960). If the assumption of a molecular counterpart to this morphogenetic principle is valid, as suggested by WALD (1960) and by COHEN (1966), then developmental data may indicate the nature of ancestral biochemistry.
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Polyanionic Glycans of Other Tissues, glandular secretions and specialized tissues and organs. Their study in secretions and in tissues other than cartilage, notochord, and bone (Chap. 7) has been comparatively unsystematic, frequently confined to a single species of a class, and meager with respect to chemical structural details. Many
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Molecular Interrelationships and Functions, (LEAKS, 1969) which may be stated as follows: 1. there exists hierarchical continuity between successive integrative levels of biological organization, and 2. there are central organizing prin­ciples to be discovered (NEEDHAM, 1968).
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