Titlebook: Concepts, Mechanisms, and New Targets for Chemotherapy; F. M. Muggia Book 1995 Springer Science+Business Media New York 1995 DNA.breast ca

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Ein Aufwachsen mit zahlreichen Anforderungenn, demonstrated encouraging activity in early clinical testing but was abandoned due to unpredictable toxicity. In 1985, Hsaing and Liu observed that the cytotoxic effect of camptothecin requires the nuclear enzyme topoisomerase I [2]. This finding coincided with the development of the semisynthetic

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Ein Aufwachsen mit zahlreichen Anforderungenaboratory, tumor cells can be selected for resistance to a particular cytotoxin by repeated exposure to that drug. The selected cells often display crossresistance to a number of functionally and structurally distinct drugs. This drug-resistant phenotype is referred to as . (MDR). Currently, the bes

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Das Konzept der Entwicklungsaufgaben toxicity from drugs are poorly characterized. One of the most important factors for our lack of understanding of drug resistance is that patient tumor specimens are infrequently studied directly. Most of our knowledge has been obtained from in vitro studies with tumor cell lines, with a limited num

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https://doi.org/10.1007/978-3-531-91093-2xyuridylate (FdUMP) inhibition of thymidylate synthase (TS) occurs by the ordered, sequential binding of TS, FdUMP, and then 5-10-methylenetetrahydrofolate (CH.FH.) [.–.]. In cell-free kinetic systems, CH.FH. must be in excess for maximal TS-FdUMP-CH.FH. ternary complex formation and complete inhibi

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Die Suche nach der eigenen Identitäts (SCCs) [1]. Most of these cancers are easily treated and cured via a primary resection by a surgeon or dermatologist. A small portion of these, however, become locally aggressive or even metastasize. This infrequent event (approximately 25,000 cases per year) presents a difficult challenge to the

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Das Konzept der Entwicklungsaufgabenigned and developed for the treatment of breast cancer following the observation of the presence of estrogen receptors in normal breast tissue and tumors [2]. The design of the drug was based on the hypothesis that conjugation of 17-B estradiol with the alkylating agent nor-nitrogen mustard would al

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Markus Bestehornmiology, biology, and pathology of the disease.Examines the .This book is based on results of the 2010 International Symposium on Dupuytren‘s disease held in Miami, Florida, but it also includes new data and additional chapters. It is hoped that it will raise awareness of this underestimated conditi