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Titlebook: Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy; F. M. Muggia Book 1987 Martinus Nijhoff Publishers, Bost

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Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy
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Tort and Regulatory Law in Norwayce, and the most familiar examples occur with the use of methotrexate (MTX), fluorodeoxyuridine (FdUrd), and cytosine arabinoside (ara-C). The general motivation for the study of schedule-dependence is to improve the therapeutic index of a drug, i.e., to maximize the ratio of therapeutic effects to toxic effects.
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Eckhardt. Peterson,Frank J. ErbguthThe majority of viruses are associated with acute limited diseases in healthy hosts. For this reason, the development of safe and effective antiviral agents has until recently been slow.
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Role of preclinical pharmacology in phase I clinical trials: Considerations of schedule-dependencece, and the most familiar examples occur with the use of methotrexate (MTX), fluorodeoxyuridine (FdUrd), and cytosine arabinoside (ara-C). The general motivation for the study of schedule-dependence is to improve the therapeutic index of a drug, i.e., to maximize the ratio of therapeutic effects to toxic effects.
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The View from Law and Economicsent modelling studies, suggesting a pharmacokinetic rationale for this method of drug delivery to tumors principally confined to the peritoneal cavity, has renewed interest in this idea [3]. In this review the basic principles of intraperitoneal chemotherapy will be presented along with a discussion
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