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Titlebook: Computational Systems Biology; Reneé Ireton,Kristina Montgomery,Jason McDermott Book 2009 Humana Press 2009 Analysis.algorithms.bioinforma

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Methods for the Inference of Biological Pathways and Networkspters of this book will need to be integrated. Other chapters of this book describe a number of methods to identify or predict network components such as physical interactions. At the end of this chapter, we speculate that some of the approaches from other chapters could be integrated and used to “a
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Exploring Pathways from Gene Co-expression to Network Dynamicslity to disease, potential usefulness of a given drug, and consequences of such external stimuli as pharmacological interventions or caloric restriction. We demonstrated the applications of CoExMiner and PathwayPro by examining gene expression profiles of ligands and receptors in cancerous and non-c
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M. H. Bala Subrahmanya,Rumki Majumdar as the driving force between interactions, we also modified the algorithm to account for combinations of more than two domains that govern a protein–protein interaction. This approach allows us to predict the previously unknown protein–protein interactions in . and ., with a degree of sensitivity a
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David B. Audretsch,Werner Bönte,Max Keilbach, and protein families. Predicted TRIs expand the networks of gene regulation for a large number of organisms. The integration of experimentally verified and predicted TRIs with other known protein–protein interactions (PPIs) gives insight into specific pathways, network motifs, and the topological
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