Titlebook: Computational Methods in Systems Biology; 18th International C Alessandro Abate,Tatjana Petrov,Verena Wolf Conference proceedings 2020 Spri

恫吓

Accelerating Reactions at the DNA Can Slow Down Transient Gene Expression a number of arbitrarily connected DNA configurations, without feedback. In our first result, we analytically show that, if all switching rates are uniformly speeded up, then, as expected, the protein transient is faster and the noise is smaller. Our second result finds that, counter-intuitively, if

Infirm

Graphical Conditions for Rate Independence in Chemical Reaction Networkshe result is completely independent of the reaction rates and depends solely on the input concentrations. The functions computed by rate-independent CRNs have been characterized mathematically as the set of piecewise linear functions from input species. However, this does not provide a mean to decid

epicondylitis

不能平静

Comparing Probabilistic and Logic Programming Approaches to Predict the Effects of Enzymes in a Neur a role in neurodegenerative diseases, in particular on Alzheimer Disease (AD). The first study used Microarray gene expression datasets from the Hippocampus of 10 AD patients and 13 healthy ones, the perturbation and thus the prediction was done .. The second one, used RNA-seq data from human umbil

Nebulous

Synthesis and Simulation of Ensembles of Boolean Networks for Cell Fate Decisionr network regulating the cell fate decisions in cancer progression. It appears that the ensemble-based approach to Boolean modelling brings new insights on the variability of synergistic interacting mutations effect concerning propensity of a cancer cell to metastasize.

inhibit

Classifier Construction in Boolean Networks Using Algebraic Methodsuse the structure of the BN and the constraints. This calls for an algebraic approach. Indeed we demonstrate that this problem can be reformulated into the language of algebraic geometry. While already interesting in itself, this allows us to use Gröbner bases to construct an algorithm for finding s

不透明

harmony

Interval Constraint Satisfaction and Optimization for Biological Homeostasis and Multistationaritychniques to find species in biochemical systems that verify homeostasis, and a similar method for testing multistationarity. We test homeostasis, ACR and multistationarity on a large collection of biochemical models from the Biomodels and DOCSS databases. The codes used in this paper are publicly available at: ..

眨眼

暗讽

Choosing, and Being, a Good Mentorf chokepoints on the growth rate is assessed on a number of metabolic networks. A software tool has been implemented to facilitate the computation of growth dependent chokepoints by the practitioners.