Titlebook: Computational Methods for GPCR Drug Discovery; Alexander Heifetz Book 2018 Springer Science+Business Media LLC 2018 G protein-coupled rece

慢慢冲刷

深陷

https://doi.org/10.1007/978-3-319-42337-1 of the putative ligand binding site from the generic retinal binding pocket to the whole receptor. In the present study, a workflow is presented starting from the selection of the target sequence, guiding through the GPCR modeling process, and finishing with ligand placement and pose validation.

不自然

Aromatic

Dave Webb,Eduardo Wills-Herrerachallenging task, and need to be taken into consideration throughout the design process. In this chapter, we focus on nuances of targeting GPCR allosteric sites in computational drug design efforts, in particular with application of docking, virtual screening, and molecular dynamics.

atopic-rhinitis

NICE

GPCR Homology Model Generation for Lead Optimization, of the putative ligand binding site from the generic retinal binding pocket to the whole receptor. In the present study, a workflow is presented starting from the selection of the target sequence, guiding through the GPCR modeling process, and finishing with ligand placement and pose validation.