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Titlebook: Computational Genome Analysis; An Introduction Richard C. Deonier,Michael S. Waterman,Simon Tavar Textbook 2005 Springer-Verlag New York 20

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Summary and Potential Applications Today, given a genome sequence, we could design PCR primers flanking the DNA of interest and by PCR could amplify just that segment. Prior to the development of rapid genomic sequencing technologies, the process was much more complicated.
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https://doi.org/10.1007/978-1-84996-030-4al pairs of linear chromosomes (humans have 23 pairs in each somatic cell), but prokaryotes typically have only one or a few circular (sometimes linear) chromosomes. The order of genes (or sets of genes) along a particular chromosome of a particular species is ordinarily conserved, and the list of g
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Summary and Potential Applicationseletal structures among tetrapods. The advent of protein and nucleic acid sequencing in molecular biology made possible comparison of organisms in terms of their DNA or the proteins that DNA encodes. These comparisons are important for a number of reasons. First, they can be used to establish evolut
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Summary and Potential Applicationsthe practicalities of the alignment process, and we demonstrate how it can be speeded up. The need for accelerated methods of alignment is connected with the potentially large number of possible alignments between two sequences (Section 6.5) and with the very large sizes of the databases that must b
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