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Titlebook: Computational Design of Membrane Proteins; Irina S. Moreira,Miguel Machuqueiro,Joana Mourão Book 2021 Springer Science+Business Media, LLC

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书目名称Computational Design of Membrane Proteins
编辑Irina S. Moreira,Miguel Machuqueiro,Joana Mourão
视频video
概述Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
丛书名称Methods in Molecular Biology
图书封面Titlebook: Computational Design of Membrane Proteins;  Irina S. Moreira,Miguel Machuqueiro,Joana Mourão Book 2021 Springer Science+Business Media, LLC
描述.This volume provides an overview of the current successes as well as pitfalls and caveats that are hindering the design of membrane proteins. Divided into six parts, chapters detail membrane transporter, FoldX force field, protein stability, G-Protein Coupled Receptors (GPCR) structures, transmembrane helices, membrane molecular dynamics (MD) simulations, pH-dependent protonation states, membrane permeability, and passive transport. Written in the highly successful .Methods in Molecular Biology .series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls... ..Authoritative and cutting-edge,  .Computational Design of Membrane Proteins .aims to ensure successful results in the further study of this vital field..Chapter 4 is available open access under a Creative CommonsAttribution 4.0 International License via link.springer.com..
出版日期Book 2021
关键词membrane insertion; structure prediction; docking algorithms; allostery; pan-assay interference compound
版次1
doihttps://doi.org/10.1007/978-1-0716-1468-6
isbn_softcover978-1-0716-1470-9
isbn_ebook978-1-0716-1468-6Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC, part of Springer Nature 2021
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Engineering of Biological Pathways: Complex Formation and Signal Transduction systems—the artificial rewiring of biological pathways. Here we describe the three-dimensional structure-based design of “rewiring” mutations using the FoldX force field. Specifically, we provide the protocol for the design and selection of interface mutations in three Ras-effector complex structur
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Homology Modeling of Class A G-Protein-Coupled Receptors in the Age of the Structure Boome target of about 30% of presently available pharmaceutical drugs. The recent boom in GPCR structures led to the structural resolution of 57 unique receptors in different states (39 receptors in inactive state only, 2 receptors in active state only and 16 receptors in different activation states). I
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Interface Prediction for GPCR Oligomerization Between Transmembrane Helicescourse of molecular evolution. The mechanisms of GPCR interactions and the reason why GPCRs interact between themselves have remained elusive. Accurate interface prediction is useful to generate guidelines for mutation and inhibition experiments and would accelerate investigations of the molecular m
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In Silico Prediction of the Binding, Folding, Insertion, and Overall Stability of Membrane-Active Peelivery, gene delivery, and antimicrobials and antibiotics. The broad appeal of MAPs is that they are infinitely variable, relatively low cost, and biocompatible. However, experimentally characterizing the specific properties of a MAP or its many variants is a low-resolution and potentially time-con
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