Titlebook: Computational Design of Ligand Binding Proteins; Barry L. Stoddard Book 2016 Springer Science+Business Media New York 2016 ligand-binding

Kennedy

书目名称Computational Design of Ligand Binding Proteins影响因子(影响力)




书目名称Computational Design of Ligand Binding Proteins影响因子(影响力)学科排名




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书目名称Computational Design of Ligand Binding Proteins网络公开度学科排名




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Perceive

Zusammenfassung der Ergebnisse,eve this is the theozyme placement and enzyme design algorithms implemented in Rosetta Molecular Modeling Suite. Here, we illustrate how to use this software to recapitulate the placement of catalytic residues and ligand into a protein using a theozyme, protein scaffold, and catalytic constraints as input.

歹徒

Barry L. StoddardIncludes cutting-edge methods and protocols.Provide step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts.Includes supplementary material

细节

Methods in Molecular Biologyhttp://image.papertrans.cn/c/image/232231.jpg

手工艺品

outer-ear

978-1-4939-8080-2Springer Science+Business Media New York 2016

outer-ear

CYT

Verschlüsselung und Substanz-Verzeichnisse–ligand interactions. However, most of the currently available computational techniques are affected by severe deficiencies in both protein and ligand conformational sampling as well as in the scoring of the obtained docking solutions. To overcome these limitations, we have recently developed Medusa

合并

Die biologische Funktion der Steroidhormone,des, respectively. GalaxySite predicts ligands that may bind the input protein and generates complex structures of the protein with the predicted ligands from the protein structure given as input or predicted from the input sequence. GalaxyPepDock takes a protein structure and a peptide sequence as

Parallel

Struktur und Nomenklatur der Steroide,for a particular target ligand are not available, artificial proteins can be computationally designed. We present a protocol based on RosettaLigand to redesign an existing protein pocket to bind a target ligand. Starting with a protein structure and the structure of the ligand, Rosetta can optimize