| 书目名称 | Complement and Kidney Disease |
| 编辑 | Peter F. Zipfel |
| 视频video | http://file.papertrans.cn/232/231285/231285.mp4 |
| 概述 | Role of genetic mutations in regulator proteins.New therapies in human kidney diseases.Prof. Zipfel is a well renowned scientist in this area of research.Includes supplementary material: |
| 丛书名称 | Progress in Inflammation Research |
| 图书封面 |  |
| 描述 | .It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.. |
| 出版日期 | Book 2006 |
| 关键词 | Complement system; Kidney diseases; biology; diseases; glomerulonephritis; kidney; membrane; molecular biol |
| 版次 | 1 |
| doi | https://doi.org/10.1007/3-7643-7428-4 |
| isbn_ebook | 978-3-7643-7428-0Series ISSN 1422-7746 Series E-ISSN 2296-4525 |
| issn_series | 1422-7746 |
| copyright | Birkhäuser Basel 2006 |
|Archiver|手机版|小黑屋|
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