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Titlebook: Combined Modality Therapy of Gastrointestinal Tract Cancer; Peter Schlag,Peter Hohenberger,Urs Metzger Conference proceedings 1988 Springe

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Smoothing a Critical TransitionRadiotherapy is the usual treatment for inoperable esophageal carcinoma. Results published before 1976, when this trial was begun were very modest, except for those of Pearson [1], The 1-year survival rate varies from 15% to 30%, and 5-year survival rates were about 5% [2–7].
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Smoothness Priors Analysis of Time SeriesIn an attempt to improve the conservative treatment of inoperable esophageal cancer we began 10 years ago to use the combined chemo-radiotherapy approach. Before conducting clinical trials we investigated the interaction of cytostatics and radiation in vitro on various cell lines.
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Controlled Clinical Trial for the Treatment of Patients with Inoperable Esophageal Carcinoma: A StudRadiotherapy is the usual treatment for inoperable esophageal carcinoma. Results published before 1976, when this trial was begun were very modest, except for those of Pearson [1], The 1-year survival rate varies from 15% to 30%, and 5-year survival rates were about 5% [2–7].
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Phase-III Clinical Trial of Adjuvant FAM2 (5-FU, Adriamycin and Mitomycin C) vs Control in ResectablDespite a reported decrease in incidence, gastric carcinoma remains a major oncologic problem in Western Europe. Surgery is at present the only hope for cure. The 5-year survival after curative surgery is about 40% for stage 2 and 20% for stage 3.
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Preoperative Radiotherapy and Radical Surgery as Combined Treatment in Rectal CancerIn 1976, the Gastrointestinal Group of the EORTC activated a clinical trial on rectal cancer with the aim of studying the efficacy of high-dose preoperative irradiation therapy (34.5 Gy) as an adjuvant before radical surgery. This was a multicentric prospective phase-III clinical trial.
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