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Titlebook: Colon Cancer Prevention; Dietary Modulation o American Institute for Cancer Research Book 1999 The Editor(s) (if applicable) and The Author

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书目名称Colon Cancer Prevention
副标题Dietary Modulation o
编辑American Institute for Cancer Research
视频videohttp://file.papertrans.cn/230/229659/229659.mp4
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Colon Cancer Prevention; Dietary Modulation o American Institute for Cancer Research Book 1999 The Editor(s) (if applicable) and The Author
描述The Eighth Annual Research Conference of the American Institute for Cancer Research, held in Washington, D.C., September 3-4, 1998, was on the subject "Colon Cancer Prevention: Dietary Modulation of Cellular and Molecular Mechanisms," with participants representing various disciplines interested in this area. One of the speak­ ers provided an appropriate quote from 17th century physician Thomas Adams: "Pre­ vention is better than healing because it saves the labor of being sick," which aptly describes the need for the prevention of cancer. An overview of normal and abnormal colonic development emphasized that although the typical human colon undergoes 1013 cell divisions by age 60, with the asso­ ciated possibilities for error, relatively few colon tumors develop. Since dietary modu­ lation leads to extremely small changes in colonic cells over a long period, animal models are useful to time, observe, and delineate the events associated with colon cancer. In the development colon cancer, the inactivation of the adenomatous polyposis coli (Apc) gene is one of the earliest known events. Normally Apc downregulates the cellular protein beta-catenin, but this is lost during cancer devel
出版日期Book 1999
关键词apoptosis; cancer prevention; carcinogenesis; cell; genetics; inflammation; prevention
版次1
doihttps://doi.org/10.1007/978-1-4615-4149-3
isbn_softcover978-1-4613-6861-8
isbn_ebook978-1-4615-4149-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
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Digested Fiber from Wheat Bran Induces cdk Inhibitors which Block Colon Epithelial Cells in G1,ive against the development of colon cancer because they cause growth arrest by inducing cyclin-directed kinase (cdk) inhibitors. A more quiescent colonic epithelium is less susceptible to mutagens which can lead to mutations or deletions in the major genes implicated in the progression to colon can
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The Genetics of Hereditary Non-Polyposis Colorectal Cancer and Non-Polypotic Colon Cancer,ence of three affected relatives from two generations is compatible with autosomal dominant inheritance and fulfils the international diagnostic (”Amsterdam”) criteria for hereditary non-polyposis colorectal cancer, HNPCC..
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Familial Association,of that expected by chance. The genes that are mutated in the rare syndromes are now known and the cellular processes related to these genes are being elucidated. Common familial clustering is also thought to arise from inherited susceptibility, based on segregation studies, but the underlying genes
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