书目名称 | Colon Cancer Prevention | 副标题 | Dietary Modulation o | 编辑 | American Institute for Cancer Research | 视频video | http://file.papertrans.cn/230/229659/229659.mp4 | 丛书名称 | Advances in Experimental Medicine and Biology | 图书封面 |  | 描述 | The Eighth Annual Research Conference of the American Institute for Cancer Research, held in Washington, D.C., September 3-4, 1998, was on the subject "Colon Cancer Prevention: Dietary Modulation of Cellular and Molecular Mechanisms," with participants representing various disciplines interested in this area. One of the speak ers provided an appropriate quote from 17th century physician Thomas Adams: "Pre vention is better than healing because it saves the labor of being sick," which aptly describes the need for the prevention of cancer. An overview of normal and abnormal colonic development emphasized that although the typical human colon undergoes 1013 cell divisions by age 60, with the asso ciated possibilities for error, relatively few colon tumors develop. Since dietary modu lation leads to extremely small changes in colonic cells over a long period, animal models are useful to time, observe, and delineate the events associated with colon cancer. In the development colon cancer, the inactivation of the adenomatous polyposis coli (Apc) gene is one of the earliest known events. Normally Apc downregulates the cellular protein beta-catenin, but this is lost during cancer devel | 出版日期 | Book 1999 | 关键词 | apoptosis; cancer prevention; carcinogenesis; cell; genetics; inflammation; prevention | 版次 | 1 | doi | https://doi.org/10.1007/978-1-4615-4149-3 | isbn_softcover | 978-1-4613-6861-8 | isbn_ebook | 978-1-4615-4149-3Series ISSN 0065-2598 Series E-ISSN 2214-8019 | issn_series | 0065-2598 | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
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