Titlebook: Cognitive Enhancement; Kathleen M. Kantak,Joseph G. Wettstein Book 2015 Springer International Publishing Switzerland 2015 Alzheimer‘s Dis

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Animal Paradigms to Assess Cognition with Translation to Humansd incorporating non-rodent species (e.g., non-human primates) that may enable a closer comparison to humans, an improvement in the translatability of the results will be possible. This chapter focuses on some promising translational cognitive paradigms for use in rodents, non-human primates, and hum

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Signaling Pathways Relevant to Cognition-Enhancing Drug Targetss receptors, downstream signaling effectors [e.g., calcium/calmodulin-dependent protein kinase II (CaMKII), protein kinase C (PKC), extracellular signal-regulated kinases (ERK), mammalian target of rapamycin (mTOR), cAMP response element-binding protein (CREB)], associated immediate early gene (e.g.

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Role of Adult Hippocampal Neurogenesis in Cognition in Physiology and Disease: Pharmacological Targeion, recent genetic approaches have shown that promoting neurogenesis can positively modulate cognition associated with both physiology and disease. Thus the discovery of signaling pathways that enhance adult neurogenesis may lead to therapeutic strategies for improving memory loss due to aging or d

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Attentionts for disorders of attention. These paradigms include two tasks of sustained attention that were developed as rodent analogues of the human Continuous Performance Task (CPT), the Five-Choice Serial Reaction Time Task (5-CSRTT) and the more recently introduced Five-Choice Continuous Performance Task

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Methods for Delivering and Evaluating the Efficacy of Cognitive Enhancementcan be facilitated through either pharmacological or remediation strategies. The critical goals of cognitive enhancement are to improve everyday functioning in multiple domains. This chapter describes the strategies that are most desirable for the treatment of cognitive impairments and detection of

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Animal Paradigms to Assess Cognition with Translation to Humanst others. Impairments in cognition are prevalent in many neuropsychiatric and neurological disorders with few viable treatment options. The development of new therapies is challenging, and poor efficacy in clinical development continues to be one of the most consistent reasons compounds fail to adva