Titlebook: Clinical and Preclinical Models for Maximizing Healthspan; Methods and Protocol Paul C. Guest Book 2020 Springer Science+Business Media, LL

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Protocol for the Use of the Ketogenic Diet in Preclinical and Clinical Practiceelaying disease onset. Here, we review the commonly used best practices involved in applications of the ketogenic diet to facilitate its translation into clinical use. The findings reveal that better education of physicians is essential for applying the optimum diet and monitoring its effects in cli

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Model for Studying the Effects of Chronic Metabolic Disease on Endogenous Bone Marrow Stem Cell Popus mellitus (DM) where the multifunctional properties (viability, proliferation, paracrine secretion, multilineage differentiation) of bone marrow resident mesenchymal stem cells (MSCs) can be affected. The growth and viability impairments make it difficult to study the underlying molecular mechanism

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Investigating Alcohol Behavior and Physiology Using Drosophila melanogasterime, and the array of tools for spatial and temporal gene manipulation. The relatively short lifespan of . (60–80 days) and the high degree of molecular conservation across species make . ideal to study the complexities of aging. Alcohol is the most abused drug worldwide and alcohol use disorders re

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Visualizing and Evaluating Cancer Cell Growth and Invasion by a Novel 3D Culture System culture system, which is more suitable for mimicking the in vivo microenvironment of cultured tumor cells ex vivo. SeedEZ is a novel and versatile tool that allows culturing of different types of cells with user convenience and in a desired sequence. This system provides a bridge between traditiona

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