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Titlebook: Clinical Use of Anti-infective Agents; A Guide on How to Pr Robert W. Finberg,Roy Guharoy Book 2021Latest edition Springer Nature Switzerla

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Penicillinse staphylococcal wound infections to gonorrhea. Initially isolated as natural products of fungi, they have had an important role in medicine and have actually permanently altered the genetics of bacteria throughout the world. These drugs are characterized by the presence of the beta-lactam ring (Fig
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Vancomycin Dosing: New Area-Under-the-Curve-Based Therapeutic Monitoring eliminated by the kidney, and renal clearance averages 81–86%. Traditionally, serum trough level has been used for therapeutic monitoring of vancomycin. Conventional dosing consists of weight-based dosing (e.g., 15 mg/kg q12h) and then checking a trough level after four doses.
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Aminoglycosidesy of streptomycin in 1947. Amikacin, gentamicin, kanamycin, netilmicin, neomycin, streptomycin, paromomycin, and tobramycin are currently approved by the FDA for use in the United States. Among these, amikacin, gentamicin, and tobramycin are most frequently used. Because of the availability of less
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MacrolidesFig. 11.1). They are derived from .. Azithromycin and clarithromycin are derived from structural modifications of erythromycin and result in improved absorption, dosing, spectrum of activity, and administration. Clarithromycin has the same 14-membered lactone ring as erythromycin replacing the hydro
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Tetracyclinesvity, their current clinical use is primarily for the treatment of intracellular organisms like ., ., and .. They are also used as alternative agents for the treatment of syphilis in the case of penicillin allergy.
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Pleuromutilindministration (FDA). Lefamulin’s novel mechanism of action is different than that of other approved antibiotics. It is available in both oral and intravenous forms and offers a broad spectrum of activity.
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Antimicrobial Stewardship: Evolution into the Twenty-First Centuryle in the United States become infected with antibiotic-resistant bacteria—a fact that has substantial implications for patient care outcomes. Infections with antibiotic-resistant bacteria are associated with increased morbidity and mortality and increased length of hospital stay—resulting in a huge
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