Titlebook: Clinical Trials; Timothy M. Pawlik,Julie A. Sosa Book 2020Latest edition Springer Nature Switzerland AG 2020 Clinical trials.Education.Sur

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Pragmatic Trials and Approaches to Transforming Care,to be effective in broader settings. This phenomenon is called regression to the mean [1]. So one way to try to approach the assessment of drug, device, and surgical interventions is to evaluate them using a pragmatic trial approach.This establishes a broader base for the intervention and, prospecti

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The Budget, 1993–2003, and 45–58% in 1962–1966 (Hormos et al., JAMA 308(22):2343–4, 2012; Moses and Dorse, JAMA 308(22):2341–2, 2012; Office of Budget, National Institutes of Health (NIH) Price indexes). In 2018, the NIH received 28,072 applications for an RO1 grant out of which just 5003 were approved corresp

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Generating a Testable Hypothesis and Underlying Principles of Clinical Trials,ion(s). Thus, thorough knowledge of the underlying principles of clinical trials is required for any investigator choosing to embark on such an endeavor. This chapter will elaborate on three important aspects of clinical trial development: defining clinical trials, developing a research question, an

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