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Titlebook: Clinical Pharmacology in Psychiatry; Selectivity in Psych Svein G. Dahl (Professor of Pharmacology),Lars F. Conference proceedings 1987 Sp

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Correlating Pharmacokinetics and Pharmacodynamics of Benzodiazepines: Problems and Assumptionsn benzodiazepine disposition, and alterations in kinetics due to drug interactions. The study of benzodiazepine pharmacokinetics has elucidated much about the general mechanisms controlling the biotransformation of foreign chemicals, and factors influencing drug disposition.
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Benzodiazepine-Serotonin Interactions in Manses that are more relevant to the clinical, anxiolytic/anticonvulsant effects than the sedative/anesthetic ones. For instance, Collinge et al. (1983) showed that low doses of BDZ reduced 5HT turnover in the rat. This effect persisted for at least 3 weeks.
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Clinical Studies of “Specific” Anxiolytics as Therapeutic Agents (5.1%). In this household survey it was again observed that only a relatively small percentage of those suffering from psychic distress and given a DSM III diagnosis as derived from the Hopkins Symptom Checklist criteria actually were treated for anxiety (Uhlenhuth et al. 1983).
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Regulation of Beta Adrenergic and Serotonin-S2 Receptors in Brain by Electroconvulsive Shock and Serahorski 1985). The decrease in serotonin-S. receptors may be linked to decreases in serotonin-mediated behavioral responses, but the high affinity of most of the antidepressants tested for the serotonin-S.-binding site in vitro and the possibility that the drugs block these receptors clouds this iss
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Unmittelbarer Besitz; Erwerb und Verlustnal coupling of the recognition components of the benzo-diazepine-GABA receptor chloride ionophore complex (supramolecular complex) and summarize recent findings from our laboratory demonstrating that the “effector” component of this complex, the chloride ionophore, is rapidly altered by stress.
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