Titlebook: Clinical Epidemiology; Practice and Methods Patrick S. Parfrey,Brendan J. Barrett Book 2015Latest edition Springer Science+Business Media N

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On Framing the Research Question and Choosing the Appropriate Research Designs well as statistical relevance. The hierarchy of evidence for clinical decision-making places randomized controlled trials (RCT) or systematic review of good quality RCTs at the top of the evidence pyramid. Prognostic and etiologic questions are best addressed with longitudinal cohort studies.

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Longitudinal Studies 3: Data Modeling Using Standard Regression Models and Extensions subjects or group of subjects, observations are not independent and the underlying correlation needs to be addressed in the analysis. In these circumstances extended models are necessary to handle complexities related to clustered data, and repeated measurements of time-varying predictors and/or outcomes.

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Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomesticular clinical situations. The domain coverage of commonly used generic short forms varies substantially. Individualized measurement of quality of life is possible, but resource intensive. Focus groups are useful, not only for scale development but also to confirm the appropriateness of existing i

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Book 2015Latest editionincluding critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful .

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Clinical Epidemiology978-1-4939-2428-8Series ISSN 1064-3745 Series E-ISSN 1940-6029