Titlebook: Clinical Applications of Mass Spectrometry; Methods and Protocol Uttam Garg,Catherine A. Hammett-Stabler Book 2010 Humana Press 2010 Clinic

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https://doi.org/10.1057/9781137346407eudomolecular drug ions are analyzed by a hybrid triple quadrupole linear ion trap mass spectrometer operated with a 264-drug selected ion monitoring (SRM) acquisition method that includes an information-dependant acquisition (IDA) algorithm.

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https://doi.org/10.1007/978-3-540-73014-9hniques can measure multiple analytes (>40) at one time. In recent years the scope of testing using these techniques has expanded from toxicological purposes to newborn screening to hormones, proteins, and enzymes. It is not uncommon any more to see mass spectrometry being used in the routine clinical laboratories.

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https://doi.org/10.1007/978-3-540-73014-9yopathy. Because the signs and symptoms are nonspecific, the identification of acylcarnitines characteristic of these inherited diseases is necessary for diagnosis. We describe a method for the analysis of acylcarnitines in plasma or serum samples using electrospray ionization tandem mass spectrometry.

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The Evolution of Mass Spectrometry in the Clinical Laboratory,hniques can measure multiple analytes (>40) at one time. In recent years the scope of testing using these techniques has expanded from toxicological purposes to newborn screening to hormones, proteins, and enzymes. It is not uncommon any more to see mass spectrometry being used in the routine clinical laboratories.

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Measurement of Plasma/Serum Acylcarnitines Using Tandem Mass Spectrometry,yopathy. Because the signs and symptoms are nonspecific, the identification of acylcarnitines characteristic of these inherited diseases is necessary for diagnosis. We describe a method for the analysis of acylcarnitines in plasma or serum samples using electrospray ionization tandem mass spectrometry.

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https://doi.org/10.1007/978-3-540-73014-9at least 1.0 µmol/L. Important isobaric amino acids are distinguished by chromatography or by unique patterns of fragmentation following collision-induced dissociation. The technique employs commercially available reagents and may be expanded and customized for specific clinical or research settings.