Titlebook: Circulating Nucleic Acids in Plasma and Serum; Proceedings of the 6 Peter B. Gahan Conference proceedings 2011 Springer Science+Business Me

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Presence of Nucleosomes in Cerebrospinal Fluid of Glioblastoma Patients – Potential for Therapy Moni serum and cerebrospinal fluid (CSF) of 45 patients were studied (10 with glioblastoma, 20 with non-acute neurological disorders, 10 with subarachnoid haemorrhage, and five with non-ruptured aneurysms). Patients with recurrent glioblastoma underwent tumour resection and local chemotherapy. Samples w

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Circulating Nucleosomes and DNAse in Breast Cancer Patients During Neoadjuvant Chemotherapycreased release or impaired elimination of nucleosomes contribute to serum concentrations measured. Therefore, we compared the courses of serum nucleosomes and DNAse activity, measured by ELISA techniques, in prospectively collected sera from 35 breast cancer patients receiving preoperative, neoadju

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Circulating Nucleosomes in Cancer Patients with Liver Metastases Undergoing Selective Internal Radiaetastases or liver cancer. In a prospective study, blood samples were taken from 112 patients with extensive hepatic metastases from various primary tumors (49 colorectal, 22 breast, 15 cholangiocellular and pancreatic, 7 carcinoid, 13 others) or with primary hepatic cancer (. = 6) before, and 3, 6,

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Circulating Fetal DNA/RNA in Maternal Plasma for Aneuploidy Detectionence of fetal DNA as a minor fraction with a major background of maternal DNA in maternal plasma has posed a challenge for non-invasive prenatal detection of fetal chromosomal aneuploidies. The early approaches focus on the detection of fetal-specific RNA or DNA molecules to develop strategies for c

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Reflections on a Life of CNAPS: From Circulating DNA to the Virtosomeansmission to the next generation of a modification appearing in part of a pluricellular organism. By proposing and demonstrating the existence of circulating DNA that is contained in a nucleoprotein particle – the virtosome – we refuted the germinal theory of Weisman on evolution. The virtosome also opens wide avenues in the field of medicine.

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Conference proceedings 2011lthy individuals and clinical patients. Recent developments are presented concerning the isolation, quantification and analysis of these molecules andtheir use in the identification of specific nucleic acid fragments related to a variety of clinical disorders thereby permitting their early diagnosis