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Titlebook: Circadian Clocks; Methods and Protocol Steven A. Brown Book 2021 Springer Science+Business Media, LLC, part of Springer Nature 2021 Neurosp

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Simple Kinetic Models in Molecular ChronobiologyMathematical modeling supports understanding available heterogeneous kinetic data, highlights basic mechanisms, and can guide experimental research. Here, we introduce the basic steps from a biological question to simple models providing insight into gene-regulatory mechanisms. We illustrate the gen
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Chromatin Immunoprecipitation (ChIP) from Mouse Liver Nucleihe circadian oscillator. Chromatin immunoprecipitation (ChIP) enables the detection and temporal analysis of such binding events in vivo. Here, we describe the individual steps from the generation of formaldehyde-cross-linked chromatin from mouse liver nuclei, fragmentation thereof, immunoprecipitat
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Circadian Metabolomics from Breathanels of small biomolecules fluctuating in a circadian fashion, thus enabling a more precise determination of inner time and understanding of how circadian clock operates at the molecular level. Emerging analytical techniques allowing for the determination of exhaled metabolites in breath show promi
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