Titlebook: Chronic Myeloid Neoplasias and Clonal Overlap Syndromes; Epidemiology, Pathop Richard Greil,Lisa Pleyer,Daniel Neureiter Book 2010 Springer

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Thomas Kron,Christian W. G. Lasarczykn platelets in the peripheral blood, with ensuing thrombohemorrhagic symptoms. Furthermore, mild leukocytosis, lack of hepatosplenomegaly and excellent prognosis with only rare transformation to acute leukemia are typical characteristics of this disease.

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Thomas Kron,Christian W. G. LasarczykPV in the state of Connecticut is 22 per 100,000 [.]. Only ∼5% of the patients are <40 years at diagnosis. Several studies report a higher incidence in males. The prevalence is ∼30/100,000. The incidence of thrombosis is ∼18 per 1,000 person-years [.]. If left untreated, the survival time of patient

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Diktumscharakterisierung als Sprechakt?,s. MDS is characterized by an increased but ineffective and dysplastic hematopoiesis as well as peripheral cytopenias. The abnormal hematopoietic clone partly gives rise to mature, but functionally and morphologically abnormal blood cells, and, at least in some cases, is capable of both myeloid and

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https://doi.org/10.1057/978-1-137-54642-5yeloid leukemia (CML) are relatively rare disorders. Due to the long life span of most patients with these diseases however, the prevalence is quite high, so that patients with these diseases are commonly seen in hematological outpatient departments.

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https://doi.org/10.1057/978-1-137-54642-5t can be present in adolescence or childhood on rare occasions [.]. Overall both genders are affected in approximately equivalent numbers. However, some Asian studies report a strong male preponderance [.]. The median age at diagnosis is 30 years in Caucasians and 45 years in Asian patients [.].

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https://doi.org/10.1057/978-1-137-54642-5hemoglobinuria (PNH) and T-cell large granular lymphocytic leukemia (T-LGL) (see .). All these entities are bone marrow failure disorders1 in which oligoclonal T-cell-mediated immune responses are without doubt pathophysiologically relevant. These overlap syndromes seem to form some kind of disease-