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Titlebook: Chronic Inflammation; Mechanisms and Regul Masayuki Miyasaka,Kiyoshi Takatsu Book 2016 Springer Japan 2016 Chronic diseases.Proinflammatory

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Conditions Favouring Political Theorys in gastrointestinal stem cells, and activation of Wnt signalling causes tumour formation. Moreover, TNF-α induces the expression of Noxo1 in tumour cells (a component of the NADPH oxidase 1 [NOX1] complex), resulting in the activation of reactive oxygen species (ROS) signalling. NOX1-derived ROS h
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Conditions Favouring Political Theory obesity is associated with chronic inflammation and cancer, we thought that the senescence-associated secretome could be closely involved in the inflammation and tumourigenesis accompanying obesity. In this review, I first discuss the role and the mechanism of cellular senescence, and then introduc
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Cellular and Molecular Mechanisms of Chronic Inflammation-Associated Organ Fibrosis in each organ shares a number of common characteristics. In particular, it is widely accepted that excessive amounts of ECM components are produced by activated fibroblasts that accumulate in injured tissue. In the first half of this chapter, we discuss the controversial origin of activated fibrobl
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Genetic Dissection of Autoinflammatory Syndromeents. The identification of immunoproteasome dysfunction-related autoinflammatory disorders highlights immunoproteasomes as crucial intracellular complexes in the regulation of inflammatory responses. Furthermore, analysis of this syndrome will provide new insights into the key molecular networks re
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Structural Biology of Chronic Inflammation-Associated Signalling Pathways: Toward Structure-Guided Dzyme and receptor. In the second section, we focus on the anaemia associated with inflammatory conditions, and discuss the structural insights into the iron exporter ferroportin, which plays a key role in the anaemia of chronic inflammation. These examples provide ideas for using structural informat
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The Drosophila Toll Pathway: A Model of Innate Immune Signalling Activated by Endogenous Ligandslly, we found that the Drosophila larval peptide fraction has strong stimulatory activity on the Toll receptor. These findings and future analyses are likely to provide information on the as yet unclear molecular mechanisms of ‘sterile inflammation’ in mammals.
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Macrophage Dynamics During Bone Resorption and Chronic Inflammatione, a lipid mediator, dynamically regulates both the migration and localisation of bone-resorbing macrophage precursor cells. Furthermore, we identified two distinct functional states of differentiated bone-resorbing macrophages, (‘bone-resorptive [R]’ and ‘nonresorptive [N]’), and found that Th17 ce
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