| 书目名称 | Chromatin Accessibility | | 副标题 | Methods and Protocol | | 编辑 | Georgi K. Marinov,William J. Greenleaf | | 视频video | | | 概述 | Includes cutting-edge techniques.Provides step-by-step detail essential for reproducible results.Contains key implementation advice from the experts | | 丛书名称 | Methods in Molecular Biology | | 图书封面 |  | | 描述 | This detailed volume provides a comprehensive resource covering the existing and state-of-the-art tools in the field of profiling chromatin accessibility and its dynamics. Beginning with a section on bulk-cell methods for profiling chromatin accessibility and nucleosome positioning that rely on enzymatic cleavage of accessible DNA and produce information about relative accessibility, the book continues with methods that use single-molecule and enzymatic approaches to solving the problem of mapping absolute occupancy/accessibility, emerging tools for mapping DNA accessibility and nucleosome positioning in single cells, imaging-based methods for visualizing accessible chromatin in its nuclear context, as well as computational methods for the processing and analysis of chromatin accessibility datasets. Written for the highly successful .Methods in Molecular Biology. series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. .Authoritative and up-to-date, .Chromatin Accessibility: Methods and Protocols. serves as an | | 出版日期 | Book 2023 | | 关键词 | Gene expression; Chromatin biology; Accessible DNA; Enzymatic cleavage; Nucleosome positioning; Single-ce | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-0716-2899-7 | | isbn_softcover | 978-1-0716-2901-7 | | isbn_ebook | 978-1-0716-2899-7Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
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发表于 2025-3-21 18:15:51
